The unique spin and optical properties of the nitrogen-vacancy (NV) defect center in diamond has motivated a significant research effort toward utilizing these defects for quantum information and sensing applications. In this talk I present recent efforts by my group at the University of Washington toward NV device integration to realize (1) scalable entanglement generation of spins and (2) wide-field optical detection of single super-paramagnetic particles for biological applications. For quantum entanglement generation, we are pursuing a hybrid materials approach in which gallium phosphide is used an active optical device layer with guided modes coupled evanescently to near-surface NV centers. For sensing applications, we engineer a 200 nm thick dense 2D ensemble of NV centers near the diamond surface and demonstrate wide field imaging of single 17 nm magnetite particles.